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Optogenetic regulation of embryo implantation in mice using photoactivatable CRISPR-Cas9

Embryo implantation is achieved upon successful interaction between a fertilized egg and receptive endometrium and is mediated by spatiotemporal expression of implantation-associated molecules including leukemia inhibitory factor (LIF). Here we demonstrate, in mice, that LIF knockdown via a photoact...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Takao, Tomoka, Sato, Moritoshi, Maruyama, Tetsuo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7682590/
https://ncbi.nlm.nih.gov/pubmed/33139551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2016850117
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