First-in-class humanized FSH blocking antibody targets bone and fat

Blocking the action of FSH genetically or pharmacologically in mice reduces body fat, lowers serum cholesterol, and increases bone mass, making an anti-FSH agent a potential therapeutic for three global epidemics: obesity, osteoporosis, and hypercholesterolemia. Here, we report the generation, struc...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Gera, Sakshi, Sant, Damini, Haider, Shozeb, Korkmaz, Funda, Kuo, Tan-Chun, Mathew, Mehr, Perez-Pena, Helena, Xie, Honglin, Chen, Hao, Batista, Rogerio, Ma, Kejun, Cheng, Zhen, Hadelia, Elina, Robinson, Cemre, Macdonald, Anne, Miyashita, Sari, Williams, Anthony, Jebian, Gregory, Miyashita, Hirotaka, Gumerova, Anisa, Ievleva, Kseniia, Smith, Pinar, He, Jiahuan, Ryu, Vitaly, DeMambro, Victoria, Quinn, Matthew A., Meseck, Marcia, Kim, Se-Min, Kumar, T. Rajendra, Iqbal, Jameel, New, Maria I., Lizneva, Daria, Rosen, Clifford J., Hsueh, Aaron J., Yuen, Tony, Zaidi, Mone
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7682550/
https://ncbi.nlm.nih.gov/pubmed/33127753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014588117
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