Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass

We report that two widely-used drugs for erectile dysfunction, tadalafil and vardenafil, trigger bone gain in mice through a combination of anabolic and antiresorptive actions on the skeleton. Both drugs were found to enhance osteoblastic bone formation in vivo using a unique gene footprint and to i...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Kim, Se-Min, Taneja, Charit, Perez-Pena, Helena, Ryu, Vitaly, Gumerova, Anisa, Li, Wenliang, Ahmad, Naseer, Zhu, Ling-Ling, Liu, Peng, Mathew, Mehr, Korkmaz, Funda, Gera, Sakshi, Sant, Damini, Hadelia, Elina, Ievleva, Kseniia, Kuo, Tan-Chun, Miyashita, Hirotaka, Liu, Li, Tourkova, Irina, Stanley, Sarah, Lizneva, Daria, Iqbal, Jameel, Sun, Li, Tamler, Ronald, Blair, Harry C., New, Maria I., Haider, Shozeb, Yuen, Tony, Zaidi, Mone
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7321982/
https://ncbi.nlm.nih.gov/pubmed/32513693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2000950117
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