First-in-class humanized FSH blocking antibody targets bone and fat

Blocking the action of FSH genetically or pharmacologically in mice reduces body fat, lowers serum cholesterol, and increases bone mass, making an anti-FSH agent a potential therapeutic for three global epidemics: obesity, osteoporosis, and hypercholesterolemia. Here, we report the generation, struc...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Gera, Sakshi, Sant, Damini, Haider, Shozeb, Korkmaz, Funda, Kuo, Tan-Chun, Mathew, Mehr, Perez-Pena, Helena, Xie, Honglin, Chen, Hao, Batista, Rogerio, Ma, Kejun, Cheng, Zhen, Hadelia, Elina, Robinson, Cemre, Macdonald, Anne, Miyashita, Sari, Williams, Anthony, Jebian, Gregory, Miyashita, Hirotaka, Gumerova, Anisa, Ievleva, Kseniia, Smith, Pinar, He, Jiahuan, Ryu, Vitaly, DeMambro, Victoria, Quinn, Matthew A., Meseck, Marcia, Kim, Se-Min, Kumar, T. Rajendra, Iqbal, Jameel, New, Maria I., Lizneva, Daria, Rosen, Clifford J., Hsueh, Aaron J., Yuen, Tony, Zaidi, Mone
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7682550/
https://ncbi.nlm.nih.gov/pubmed/33127753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014588117
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge