Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis

Rationale: As the central hallmark of liver fibrosis, transdifferentiation of hepatic stellate cells (HSCs), the predominant contributor to fibrogenic hepatic myofibroblast responsible for extracellular matrix (ECM) deposition, is characterized with transcriptional and epigenetic remodeling. We aime...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Jiang, Yan, Xiang, Chan, Zhong, Fan, Zhang, Yang, Wang, Liyan, Zhao, Yuanyuan, Wang, Jiucun, Ding, Chen, Jin, Li, He, Fuchu, Wang, Haijian
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7681085/
https://ncbi.nlm.nih.gov/pubmed/33391480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.46360
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