Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis

Rationale: As the central hallmark of liver fibrosis, transdifferentiation of hepatic stellate cells (HSCs), the predominant contributor to fibrogenic hepatic myofibroblast responsible for extracellular matrix (ECM) deposition, is characterized with transcriptional and epigenetic remodeling. We aime...

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Dades bibliogràfiques
Publicat a:Theranostics
Autors principals: Jiang, Yan, Xiang, Chan, Zhong, Fan, Zhang, Yang, Wang, Liyan, Zhao, Yuanyuan, Wang, Jiucun, Ding, Chen, Jin, Li, He, Fuchu, Wang, Haijian
Format: Artigo
Idioma:Inglês
Publicat: Ivyspring International Publisher 2021
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7681085/
https://ncbi.nlm.nih.gov/pubmed/33391480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.46360
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