Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis

Rationale: As the central hallmark of liver fibrosis, transdifferentiation of hepatic stellate cells (HSCs), the predominant contributor to fibrogenic hepatic myofibroblast responsible for extracellular matrix (ECM) deposition, is characterized with transcriptional and epigenetic remodeling. We aime...

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Bibliografiske detaljer
Udgivet i:Theranostics
Main Authors: Jiang, Yan, Xiang, Chan, Zhong, Fan, Zhang, Yang, Wang, Liyan, Zhao, Yuanyuan, Wang, Jiucun, Ding, Chen, Jin, Li, He, Fuchu, Wang, Haijian
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2021
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7681085/
https://ncbi.nlm.nih.gov/pubmed/33391480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.46360
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