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Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation
Although histone H3 lysine 27 trimethylation (H3K27Me3) is associated with gene silencing, whether H3K27Me3 demethylation affects transcription and cell differentiation in vivo has remained elusive. To investigate this, we conditionally inactivated the two H3K27Me3 demethylases, Jmjd3 and Utx, in no...
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| Publicado en: | Nat Commun |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Pub. Group
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4569738/ https://ncbi.nlm.nih.gov/pubmed/26328764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9152 |
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