Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation

Although histone H3 lysine 27 trimethylation (H3K27Me3) is associated with gene silencing, whether H3K27Me3 demethylation affects transcription and cell differentiation in vivo has remained elusive. To investigate this, we conditionally inactivated the two H3K27Me3 demethylases, Jmjd3 and Utx, in no...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Manna, Sugata, Kim, Jong Kyong, Baugé, Catherine, Cam, Margaret, Zhao, Yongmei, Shetty, Jyoti, Vacchio, Melanie S., Castro, Ehydel, Tran, Bao, Tessarollo, Lino, Bosselut, Rémy
Format: Artigo
Jezik:Inglês
Izdano: Nature Pub. Group 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569738/
https://ncbi.nlm.nih.gov/pubmed/26328764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9152
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