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Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation
Although histone H3 lysine 27 trimethylation (H3K27Me3) is associated with gene silencing, whether H3K27Me3 demethylation affects transcription and cell differentiation in vivo has remained elusive. To investigate this, we conditionally inactivated the two H3K27Me3 demethylases, Jmjd3 and Utx, in no...
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| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Pub. Group
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4569738/ https://ncbi.nlm.nih.gov/pubmed/26328764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9152 |
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