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How age and infection history shape the antigen‐specific CD8(+) T‐cell repertoire: Implications for vaccination strategies in older adults

Older adults often show signs of impaired CD8(+) T‐cell immunity, reflected by weaker responses against new infections and vaccinations, and decreased protection against reinfection. This immune impairment is in part thought to be the consequence of a decrease in both T‐cell numbers and repertoire d...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Lanfermeijer, Josien, Borghans, José A. M., van Baarle, Debbie
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7681067/
https://ncbi.nlm.nih.gov/pubmed/33078890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13262
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