Complex T-Cell Receptor Repertoire Dynamics Underlie the CD8(+) T-Cell Response to HIV-1

Although CD8(+) T cells are important for the control of HIV-1 in vivo, the precise correlates of immune efficacy remain unclear. In this study, we conducted a comprehensive analysis of viral sequence variation and T-cell receptor (TCR) repertoire composition across multiple epitope specificities in...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Costa, Ana I., Koning, Dan, Ladell, Kristin, McLaren, James E., Grady, Bart P. X., Schellens, Ingrid M. M., van Ham, Petra, Nijhuis, Monique, Borghans, José A. M., Keşmir, Can, Price, David A., van Baarle, Debbie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301094/
https://ncbi.nlm.nih.gov/pubmed/25320304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01765-14
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