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Designed parasite-selective rhomboid inhibitors block invasion and clear blood-stage malaria
Rhomboid intramembrane proteases regulate patho-physiological processes, but their targeting in a disease context has never been achieved. We decoded the atypical substrate specificity of malaria rhomboid PfROM4, but found, unexpectedly, that it results from ‘steric exclusion’: PfROM4 and canonical...
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| Publicado en: | Cell Chem Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7680425/ https://ncbi.nlm.nih.gov/pubmed/32888502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.08.011 |
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