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Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release
Protein cleavage inside the cell membrane triggers various patho-physiological signaling pathways, but the mechanism of catalysis is poorly understood. We solved ten structures of the Escherichia coli rhomboid protease in a bicelle membrane undergoing time-resolved steps that encompass the entire pr...
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| Publicado en: | Nat Struct Mol Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6858540/ https://ncbi.nlm.nih.gov/pubmed/31570873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0296-9 |
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