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In vivo analysis reveals substrate-gating mutants of a rhomboid intramembrane protease display increased activity in living cells
Intramembrane proteases hydrolyze peptide bonds within cell membranes. Recent crystal structures revealed that rhomboid intramembrane proteases contain a hydrated active site that opens to the outside of the cell, but is protected laterally from membrane lipids by protein segments. Using E. coli rho...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2678756/ https://ncbi.nlm.nih.gov/pubmed/18979634 |
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