Txn2 haplodeficiency does not affect cochlear antioxidant defenses or accelerate the progression of cochlear cell loss or hearing loss across the lifespan

Thioredoxin 2 (TXN2) is a small redox protein found in nearly all organisms. As a mitochondrial member of the thioredoxin antioxidant defense system, TXN2 interacts with peroxiredoxin 3 (PRDX3) to remove hydrogen peroxide. Accordingly, TXN2 is thought to play an important role in maintaining the app...

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Publicat a:Exp Gerontol
Autors principals: Kim, Mi-Jung, Han, Chul, White, Karessa, Park, Hyo-Jin, Ding, Dalian, Boyd, Kevin, Rothenberger, Christina, Bose, Upal, Carmichael, Peter, Linser, Paul J., Tanokura, Masaru, Salvi, Richard, Someya, Shinichi
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7680416/
https://ncbi.nlm.nih.gov/pubmed/32866605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2020.111078
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