GSR is not essential for the maintenance of antioxidant defenses in mouse cochlea: Possible role of the thioredoxin system as a functional backup for GSR

Glutathione reductase (GSR), a key member of the glutathione antioxidant defense system, converts oxidized glutathione (GSSG) to reduced glutathione (GSH) and maintains the intracellular glutathione redox state to protect the cells from oxidative damage. Previous reports have shown that Gsr deficien...

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Udgivet i:PLoS One
Main Authors: Han, Chul, Kim, Mi-Jung, Ding, Dalian, Park, Hyo-Jin, White, Karessa, Walker, Logan, Gu, Tongjun, Tanokura, Masaru, Yamasoba, Tatsuya, Linser, Paul, Salvi, Richard, Someya, Shinichi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501606/
https://ncbi.nlm.nih.gov/pubmed/28686716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180817
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