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Delineation of metabolic responses of Npc1(−/−nih) mice lacking the cholesterol-esterifying enzyme SOAT2 to acute treatment with 2-hydroxypropyl-β-cyclodextrin

Lipids present in lipoproteins cleared from the circulation are processed sequentially by three major proteins within the late endosomal / lysosomal (E/L) compartment of all cells: lysosomal acid lipase (LAL), Niemann-Pick (NPC) C2 and NPC1. When all three of these proteins are functioning normally,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Steroids
Hauptverfasser: Ramirez, Charina M., Taylor, Anna M., Lopez, Adam M., Repa, Joyce J., Turley, Stephen D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7680374/
https://ncbi.nlm.nih.gov/pubmed/32890578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.steroids.2020.108725
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