Systemic administration of 2-hydroxypropyl-β-cyclodextrin to symptomatic Npc1-deficient mice slows cholesterol sequestration in the major organs and improves liver function

Lignende værker

• Delineation of metabolic responses of Npc1(−/−nih) mice lacking the cholesterol-esterifying enzyme SOAT2 to acute treatment with 2-hydroxypropyl-β-cyclodextrin
  af: Ramirez, Charina M., et al.
  Udgivet: (2020)
• Cyclodextrin overcomes the transport defect in nearly every organ of NPC1 mice leading to excretion of sequestered cholesterol as bile acid
  af: Liu, Benny, et al.
  Udgivet: (2010)
• Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations
  af: Ramirez, Charina M., et al.
  Udgivet: (2011)
• Differential Effects of 2-Hydroxypropyl-Cyclodextrins on Lipid Accumulation in Npc1-Null Cells
  af: Hoque, Sanzana, et al.
  Udgivet: (2020)
• Normalization of Cholesterol Homeostasis by 2-Hydroxypropyl-β-cyclodextrin in Neurons and Glia from Niemann-Pick C1 (NPC1)-deficient Mice
  af: Peake, Kyle B., et al.
  Udgivet: (2012)