Differential Effects of 2-Hydroxypropyl-Cyclodextrins on Lipid Accumulation in Npc1-Null Cells

Niemann–Pick disease type C (NPC) is an autosomal recessive disorder characterized by abnormal accumulation of free cholesterol and sphingolipids in lysosomes. The iminosugar miglustat, which inhibits hexosylceramide synthesis, is used for NPC treatment, and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD),...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Int J Mol Sci
Main Authors: Hoque, Sanzana, Kondo, Yuki, Sakata, Nodoka, Yamada, Yusei, Fukaura, Madoka, Higashi, Taishi, Motoyama, Keiichi, Arima, Hidetoshi, Higaki, Katsumi, Hayashi, Akio, Komiya, Takaki, Ishitsuka, Yoichi, Irie, Tetsumi
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038050/
https://ncbi.nlm.nih.gov/pubmed/32019132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21030898
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares