Synthesis of multi-lactose-appended β-cyclodextrin and its cholesterol-lowering effects in Niemann–Pick type C disease-like HepG2 cells

Niemann–Pick type C (NPC) disease, characterized by intracellular accumulation of unesterified cholesterol and other lipids owing to defects in two proteins NPC1 and NPC2, causes neurodegeneration and other fatal neurovisceral symptoms. Currently, treatment of NPC involves the use of 2-hydroxypropyl...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Beilstein J Org Chem
Päätekijät: Motoyama, Keiichi, Nishiyama, Rena, Maeda, Yuki, Higashi, Taishi, Ishitsuka, Yoichi, Kondo, Yuki, Irie, Tetsumi, Era, Takumi, Arima, Hidetoshi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Beilstein-Institut 2017
Aiheet:
Full Research Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238562/
https://ncbi.nlm.nih.gov/pubmed/28179943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.13.2
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