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Synthesis of multi-lactose-appended β-cyclodextrin and its cholesterol-lowering effects in Niemann–Pick type C disease-like HepG2 cells

Niemann–Pick type C (NPC) disease, characterized by intracellular accumulation of unesterified cholesterol and other lipids owing to defects in two proteins NPC1 and NPC2, causes neurodegeneration and other fatal neurovisceral symptoms. Currently, treatment of NPC involves the use of 2-hydroxypropyl...

詳細記述

保存先:
書誌詳細
出版年:Beilstein J Org Chem
主要な著者: Motoyama, Keiichi, Nishiyama, Rena, Maeda, Yuki, Higashi, Taishi, Ishitsuka, Yoichi, Kondo, Yuki, Irie, Tetsumi, Era, Takumi, Arima, Hidetoshi
フォーマット: Artigo
言語:Inglês
出版事項: Beilstein-Institut 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238562/
https://ncbi.nlm.nih.gov/pubmed/28179943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.13.2
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