Synthesis of multi-lactose-appended β-cyclodextrin and its cholesterol-lowering effects in Niemann–Pick type C disease-like HepG2 cells

Niemann–Pick type C (NPC) disease, characterized by intracellular accumulation of unesterified cholesterol and other lipids owing to defects in two proteins NPC1 and NPC2, causes neurodegeneration and other fatal neurovisceral symptoms. Currently, treatment of NPC involves the use of 2-hydroxypropyl...

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Detalhes bibliográficos
Publicado no:Beilstein J Org Chem
Main Authors: Motoyama, Keiichi, Nishiyama, Rena, Maeda, Yuki, Higashi, Taishi, Ishitsuka, Yoichi, Kondo, Yuki, Irie, Tetsumi, Era, Takumi, Arima, Hidetoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Beilstein-Institut 2017
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Full Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238562/
https://ncbi.nlm.nih.gov/pubmed/28179943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.13.2
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