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Cholesterol lowering effects of mono-lactose-appended β-cyclodextrin in Niemann–Pick type C disease-like HepG2 cells
The Niemann–Pick type C disease (NPC) is one of inherited lysosomal storage disorders, emerges the accumulation of unesterified cholesterol in endolysosomes. Currently, 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD) has been applied for the treatment of NPC. HP-β-CyD improved hepatosplenomegaly in NPC pa...
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Udgivet i: | Beilstein J Org Chem |
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Main Authors: | , , , , , , , , , |
Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
Beilstein-Institut
2015
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4660966/ https://ncbi.nlm.nih.gov/pubmed/26664628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.11.224 |
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