Cholesterol lowering effects of mono-lactose-appended β-cyclodextrin in Niemann–Pick type C disease-like HepG2 cells

The Niemann–Pick type C disease (NPC) is one of inherited lysosomal storage disorders, emerges the accumulation of unesterified cholesterol in endolysosomes. Currently, 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD) has been applied for the treatment of NPC. HP-β-CyD improved hepatosplenomegaly in NPC pa...

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Bibliographic Details
Published in:Beilstein J Org Chem
Main Authors: Motoyama, Keiichi, Hirai, Yumi, Nishiyama, Rena, Maeda, Yuki, Higashi, Taishi, Ishitsuka, Yoichi, Kondo, Yuki, Irie, Tetsumi, Era, Takumi, Arima, Hidetoshi
Format: Artigo
Language:Inglês
Published: Beilstein-Institut 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4660966/
https://ncbi.nlm.nih.gov/pubmed/26664628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.11.224
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