Influence of Npc1 genotype on the toxicity of hydroxypropyl-β-cyclodextrin, a potentially therapeutic agent, in Niemann–Pick Type C disease models()

Hydroxypropyl-β-cyclodextrin (HPBCD) is an attractive drug candidate against Niemann–Pick Type C (NPC) disease. However, the safety of HPBCD treatment for NPC patients remains to be elucidated. In this study, we examined the acute toxicity of HPBCD in Npc1-deficient mice. When treated with HPBCD (20...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Genet Metab Rep
Main Authors: Tanaka, Yuta, Ishitsuka, Yoichi, Yamada, Yusei, Kondo, Yuki, Takeo, Toru, Nakagata, Naomi, Higashi, Taishi, Motoyama, Keiichi, Arima, Hidetoshi, Matsuo, Muneaki, Higaki, Katsumi, Ohno, Kousaku, Irie, Tetsumi
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5121301/
https://ncbi.nlm.nih.gov/pubmed/27896072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgmr.2013.12.003
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados