Intracerebroventricular Treatment with 2-Hydroxypropyl-β-Cyclodextrin Decreased Cerebellar and Hepatic Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Expression in Niemann–Pick Disease Type C Model Mice

Niemann–Pick disease type C (NPC) is a recessive hereditary disease caused by mutation of the NPC1 or NPC2 gene. It is characterized by abnormality of cellular cholesterol trafficking with severe neuronal and hepatic injury. In this study, we investigated the potential of glycoprotein nonmetastatic...

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Publicat a:Int J Mol Sci
Autors principals: Fukaura, Madoka, Ishitsuka, Yoichi, Shirakawa, Seiichi, Ushihama, Naoki, Yamada, Yusei, Kondo, Yuki, Takeo, Toru, Nakagata, Naomi, Motoyama, Keiichi, Higashi, Taishi, Arima, Hidetoshi, Kurauchi, Yuki, Seki, Takahiro, Katsuki, Hiroshi, Higaki, Katsumi, Matsuo, Muneaki, Irie, Tetsumi
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7795151/
https://ncbi.nlm.nih.gov/pubmed/33466390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22010452
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