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Cyclodextrin mediates rapid changes in lipid balance in Npc1(−/−) mice without carrying cholesterol through the bloodstream
An injection of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) to mice lacking Niemann Pick type C (NPC) protein results in delayed neurodegeneration, decreased inflammation, and prolonged lifespan. Changes in sterol balance observed in Npc1(−/−) mice 24 h after HP-β-CD administration suggest that HP-β-CD...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3466002/ https://ncbi.nlm.nih.gov/pubmed/22892156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M028241 |
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