RNAi technology targeting the FGFR3-TACC3 fusion breakpoint: an opportunity for precision medicine

BACKGROUND: Fusion genes form as a result of abnormal chromosomal rearrangements linking previously separate genes into one transcript. The FGFR3-TACC3 fusion gene (F3-T3) has been shown to drive gliomagenesis in glioblastoma (GBM), a cancer that is notoriously resistant to therapy. However, success...

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Dettagli Bibliografici
Pubblicato in:Neurooncol Adv
Autori principali: Parker Kerrigan, Brittany C, Ledbetter, Daniel, Kronowitz, Matthew, Phillips, Lynette, Gumin, Joy, Hossain, Anwar, Yang, Jing, Mendt, Mayela, Singh, Sanjay, Cogdell, David, Ene, Chibawanye, Shpall, Elizabeth, Lang, Frederick F
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Basic and Translational Investigations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7680176/
https://ncbi.nlm.nih.gov/pubmed/33241214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa132
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