Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9

CAR-T cell therapy is effective for hematologic malignancies. However, considerable numbers of patients relapse after the treatment, partially due to poor expansion and limited persistence of CAR-T cells in vivo. Here, we demonstrate that human CAR-T cells polarized and expanded under a Th9-culture...

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Vydáno v:Nat Commun
Hlavní autoři: Liu, Lintao, Bi, Enguang, Ma, Xingzhe, Xiong, Wei, Qian, Jianfei, Ye, Lingqun, Su, Pan, Wang, Qiang, Xiao, Liuling, Yang, Maojie, Lu, Yong, Yi, Qing
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7677397/
https://ncbi.nlm.nih.gov/pubmed/33214555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19672-2
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