Affinity-restricted memory B cells dominate recall responses to heterologous flaviviruses.

Memory B cells (MBCs) can respond to heterologous antigens either by molding new specificities through secondary germinal centers (GCs) or selecting pre-existing clones without further affinity maturation. To distinguish these mechanisms in flavivirus infections and immunizations, we studied recall...

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Udgivet i:Immunity
Main Authors: Wong, Rachel, Belk, Julia A., Govero, Jennifer, Uhrlaub, Jennifer L., Reinartz, Dakota, Zhao, Haiyan, Errico, John M., D’Souza, Lucas, Ripperger, Tyler J., Nikolich-Zugich, Janko, Shlomchik, Mark J., Satpathy, Ansuman T., Fremont, Daved H., Diamond, Michael S., Bhattacharya, Deepta
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7677180/
https://ncbi.nlm.nih.gov/pubmed/33010224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.09.001
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