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Dynamics-Driven Allostery Underlies Ca(2+)-Mediated Release of SERCA Inhibition by Phospholamban
Sarcoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA) and phospholamban (PLB) are essential for intracellular Ca(2+) transport in myocytes. Ca(2+)-dependent activation of SERCA-PLB provides a control function that regulates cytosolic and SR Ca(2+) levels. Although experimental and computational studies...
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| Publicado en: | Biophys J |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Biophysical Society
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7677127/ https://ncbi.nlm.nih.gov/pubmed/33069270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.09.014 |
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