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Dynamics-Driven Allostery Underlies Ca(2+)-Mediated Release of SERCA Inhibition by Phospholamban
Sarcoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA) and phospholamban (PLB) are essential for intracellular Ca(2+) transport in myocytes. Ca(2+)-dependent activation of SERCA-PLB provides a control function that regulates cytosolic and SR Ca(2+) levels. Although experimental and computational studies...
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| Udgivet i: | Biophys J |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Biophysical Society
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7677127/ https://ncbi.nlm.nih.gov/pubmed/33069270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.09.014 |
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