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The Phospholamban Pentamer Alters Function of the Sarcoplasmic Reticulum Calcium Pump SERCA

The interaction of phospholamban (PLN) with the sarco-endoplasmic reticulum Ca(2+)-ATPase (SERCA) pump is a major regulatory axis in cardiac muscle contractility. The prevailing model involves reversible inhibition of SERCA by monomeric PLN and storage of PLN as an inactive pentamer. However, this p...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Glaves, John Paul, Primeau, Joseph O., Espinoza-Fonseca, L. Michel, Lemieux, M. Joanne, Young, Howard S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6383005/
https://ncbi.nlm.nih.gov/pubmed/30712785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.01.013
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