HPS1 Regulates the Maturation of Large Dense Core Vesicles and Lysozyme Secretion in Paneth Cells

HPS1, a BLOC-3 subunit that acts as a guanine nucleotide exchange factor of Rab32/38, may play a role in the removal of VAMP7 during the maturation of large dense core vesicles of Paneth cells. Loss of HPS1 impairs lysozyme secretion and alters the composition of intestinal microbiota, which may exp...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Front Immunol
Main Authors: Yu, Jiaying, He, Xin, Wei, Aihua, Liu, Teng, Zhang, Qin, Pan, Ying, Hao, Zhenhua, Yang, Lin, Yuan, Yefeng, Zhang, Zhao, Zhang, Chang, Hao, Chanjuan, Liu, Zhihua, Li, Wei
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020
Teme:
Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674556/
https://ncbi.nlm.nih.gov/pubmed/33224134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.560110
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