HPS1 Regulates the Maturation of Large Dense Core Vesicles and Lysozyme Secretion in Paneth Cells

HPS1, a BLOC-3 subunit that acts as a guanine nucleotide exchange factor of Rab32/38, may play a role in the removal of VAMP7 during the maturation of large dense core vesicles of Paneth cells. Loss of HPS1 impairs lysozyme secretion and alters the composition of intestinal microbiota, which may exp...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Yu, Jiaying, He, Xin, Wei, Aihua, Liu, Teng, Zhang, Qin, Pan, Ying, Hao, Zhenhua, Yang, Lin, Yuan, Yefeng, Zhang, Zhao, Zhang, Chang, Hao, Chanjuan, Liu, Zhihua, Li, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674556/
https://ncbi.nlm.nih.gov/pubmed/33224134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.560110
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