HPS1 Regulates the Maturation of Large Dense Core Vesicles and Lysozyme Secretion in Paneth Cells

HPS1, a BLOC-3 subunit that acts as a guanine nucleotide exchange factor of Rab32/38, may play a role in the removal of VAMP7 during the maturation of large dense core vesicles of Paneth cells. Loss of HPS1 impairs lysozyme secretion and alters the composition of intestinal microbiota, which may exp...

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Vydáno v:Front Immunol
Hlavní autoři: Yu, Jiaying, He, Xin, Wei, Aihua, Liu, Teng, Zhang, Qin, Pan, Ying, Hao, Zhenhua, Yang, Lin, Yuan, Yefeng, Zhang, Zhao, Zhang, Chang, Hao, Chanjuan, Liu, Zhihua, Li, Wei
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674556/
https://ncbi.nlm.nih.gov/pubmed/33224134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.560110
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