Experimental sleep disruption attenuates morphine analgesia: findings from a randomized trial and implications for the opioid abuse epidemic

Preclinical studies demonstrate that sleep disruption diminishes morphine analgesia and modulates reward processing. We sought to translate these preclinical findings to humans by examining whether sleep disruption alters morphine’s analgesic and hedonic properties. We randomized 100 healthy adults...

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Publicat a:Sci Rep
Autors principals: Smith, Michael T., Mun, Chung Jung, Remeniuk, Bethany, Finan, Patrick H., Campbell, Claudia M., Buenaver, Luis F., Robinson, Mercedes, Fulton, Brook, Tompkins, David Andrew, Tremblay, Jean-Michel, Strain, Eric C., Irwin, Michael R.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674501/
https://ncbi.nlm.nih.gov/pubmed/33208831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76934-1
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