Experimental sleep disruption attenuates morphine analgesia: findings from a randomized trial and implications for the opioid abuse epidemic

Preclinical studies demonstrate that sleep disruption diminishes morphine analgesia and modulates reward processing. We sought to translate these preclinical findings to humans by examining whether sleep disruption alters morphine’s analgesic and hedonic properties. We randomized 100 healthy adults...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Smith, Michael T., Mun, Chung Jung, Remeniuk, Bethany, Finan, Patrick H., Campbell, Claudia M., Buenaver, Luis F., Robinson, Mercedes, Fulton, Brook, Tompkins, David Andrew, Tremblay, Jean-Michel, Strain, Eric C., Irwin, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674501/
https://ncbi.nlm.nih.gov/pubmed/33208831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76934-1
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