Piperaquine Exposure Is Altered by Pregnancy, HIV, and Nutritional Status in Ugandan Women

Dihydroartemisinin-piperaquine (DHA-PQ) provides highly effective therapy and chemoprevention for malaria in pregnant African women. PQ concentrations of >10.3 ng/ml have been associated with reduced maternal parasitemia, placental malaria, and improved birth outcomes. We characterized the popula...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Hughes, Emma, Imperial, Marjorie, Wallender, Erika, Kajubi, Richard, Huang, Liusheng, Jagannathan, Prasanna, Zhang, Nan, Kakuru, Abel, Natureeba, Paul, Mwima, Moses W., Muhindo, Mary, Mwebaza, Norah, Clark, Tamara D., Opira, Bishop, Nakalembe, Miriam, Havlir, Diane, Kamya, Moses, Rosenthal, Philip J., Dorsey, Grant, Aweeka, Francesca, Savic, Radojka M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674024/
https://ncbi.nlm.nih.gov/pubmed/33020153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01013-20
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