Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells

The actin cytoskeletal regulator Wiskott Aldrich syndrome protein (WASp) has been implicated in maintenance of the autophagy-inflammasome axis in innate murine immune cells. Here, we show that WASp deficiency is associated with impaired rapamycin-induced autophagosome formation and trafficking to ly...

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Bibliographic Details
Published in:eLife
Main Authors: Rivers, Elizabeth, Rai, Rajeev, Lötscher, Jonas, Hollinshead, Michael, Markelj, Gasper, Thaventhiran, James, Worth, Austen, Cavazza, Alessia, Hess, Christoph, Bajaj-Elliott, Mona, Thrasher, Adrian J
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2020
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7673780/
https://ncbi.nlm.nih.gov/pubmed/33135633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.55547
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