Methamphetamine induces cardiomyopathy by Sigmar1 inhibition-dependent impairment of mitochondrial dynamics and function

Methamphetamine-associated cardiomyopathy is the leading cause of death linked with illicit drug use. Here we show that Sigmar1 is a therapeutic target for methamphetamine-associated cardiomyopathy and defined the molecular mechanisms using autopsy samples of human hearts, and a mouse model of “bing...

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Udgivet i:Commun Biol
Main Authors: Abdullah, Chowdhury S., Aishwarya, Richa, Alam, Shafiul, Morshed, Mahboob, Remex, Naznin Sultana, Nitu, Sadia, Kolluru, Gopi K., Traylor, James, Miriyala, Sumitra, Panchatcharam, Manikandan, Hartman, Brandon, King, Judy, Bhuiyan, Mohammad Alfrad Nobel, Chandran, Sunitha, Woolard, Matthew D., Yu, Xiuping, Goeders, Nicholas E., Dominic, Paari, Arnold, Connie L., Stokes, Karen, Kevil, Christopher G., Orr, A. Wayne, Bhuiyan, Md. Shenuarin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7673131/
https://ncbi.nlm.nih.gov/pubmed/33203971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01408-z
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