Suppression of DNA Double-Strand Break Formation by DNA Polymerase β in Active DNA Demethylation Is Required for Development of Hippocampal Pyramidal Neurons

Genome stability is essential for brain development and function, as de novo mutations during neuronal development cause psychiatric disorders. However, the contribution of DNA repair to genome stability in neurons remains elusive. Here, we demonstrate that the base excision repair protein DNA polym...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Uyeda, Akiko, Onishi, Kohei, Hirayama, Teruyoshi, Hattori, Satoko, Miyakawa, Tsuyoshi, Yagi, Takeshi, Yamamoto, Nobuhiko, Sugo, Noriyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7672999/
https://ncbi.nlm.nih.gov/pubmed/33087478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0319-20.2020
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