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Active cytosine demethylation triggered by a nuclear receptor involves DNA strand breaks
Cytosine methylation at CpG dinucleotides contributes to the epigenetic maintenance of gene silencing. Dynamic reprogramming of DNA methylation patterns is believed to play a key role during development and differentiation in vertebrates. The mechanisms of DNA demethylation remain unclear and contro...
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Main Authors: | , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2006
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1544051/ https://ncbi.nlm.nih.gov/pubmed/16840560 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601793103 |
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