Metabolic interaction between amino acid deprivation and cisplatin synergistically reduces phosphoribosyl-pyrophosphate and augments cisplatin cytotoxicity

Cisplatin is a mainstay of cancer chemotherapy. It forms DNA adducts, thereby activating poly(ADP-ribose) polymerases (PARPs) to initiate DNA repair. The PARP substrate NAD(+) is synthesized from 5-phosphoribose-1-pyrophosphate (PRPP), and we found that treating cells for 6 h with cisplatin reduced...

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Udgivet i:Sci Rep
Main Authors: Wahwah, Nisreen, Dhar, Debanjan, Chen, Hui, Zhuang, Shunhui, Chan, Adriano, Casteel, Darren E., Kalyanaraman, Hema, Pilz, Renate B., Boss, Gerry R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7670436/
https://ncbi.nlm.nih.gov/pubmed/33199755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76958-7
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