Metabolic interaction between amino acid deprivation and cisplatin synergistically reduces phosphoribosyl-pyrophosphate and augments cisplatin cytotoxicity

Cisplatin is a mainstay of cancer chemotherapy. It forms DNA adducts, thereby activating poly(ADP-ribose) polymerases (PARPs) to initiate DNA repair. The PARP substrate NAD(+) is synthesized from 5-phosphoribose-1-pyrophosphate (PRPP), and we found that treating cells for 6 h with cisplatin reduced...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Wahwah, Nisreen, Dhar, Debanjan, Chen, Hui, Zhuang, Shunhui, Chan, Adriano, Casteel, Darren E., Kalyanaraman, Hema, Pilz, Renate B., Boss, Gerry R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7670436/
https://ncbi.nlm.nih.gov/pubmed/33199755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76958-7
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados