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Regulation of p53 by the 14-3-3 protein interaction network: new opportunities for drug discovery in cancer
Most cancers evolve to disable the p53 pathway, a key tumour suppressor mechanism that prevents transformation and malignant cell growth. However, only ~50% exhibit inactivating mutations of p53, while in the rest its activity is suppressed by changes in the proteins that modulate the pathway. There...
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| Publicado no: | Cell Death Discov |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7669891/ https://ncbi.nlm.nih.gov/pubmed/33298896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-020-00362-3 |
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