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Translesion synthesis of 6-nitrochrysene-derived 2ʹ-deoxyadenosine adduct in human cells

6-Nitrochrysene (6-NC) is a potent mutagen in bacteria and carcinogenic in animals. It is the most potent carcinogen ever tested in newborn mouse assay. DNA lesions resulting from 6-NC modification are likely to induce mutations if they are not removed by cellular defense pathways prior to DNA repli...

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Detalhes bibliográficos
Publicado no:DNA Repair (Amst)
Main Authors: Powell, Brent V., Bacurio, Jan Henric T., Basu, Ashis K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7669628/
https://ncbi.nlm.nih.gov/pubmed/32721818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2020.102935
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