An Adenine-DNA Adduct Derived from Nitroreduction of 6-Nitrochrysene is more Resistant to Nucleotide Excision Repair than Guanine-DNA Adducts

Previous studies in rats, mice and in vitro systems showed that 6-NC can be metabolically activated by two major pathways: 1) the formation of N-hydroxy-6-aminochrysene by nitroreduction to yield three major adducts: N-(dG-8-yl)-6-AC, 5-(dG-N(2)-yl)-6-AC and N-(dA-8-yl)-6-AC, and 2) the formation of...

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Main Authors: Krzeminski, Jacek, Kropachev, Konstantin, Reeves, Dara, Kolbanovskiy, Aleksandr, Kolbanovskiy, Marina, Chen, Kun-Ming, Sharma, Arun K., Geacintov, Nicholas, Amin, Shantu, El-Bayoumy, Karam
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883057/
https://ncbi.nlm.nih.gov/pubmed/24112095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx400296x
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