Wake-sleep cycles are severely disrupted by diseases affecting cytoplasmic homeostasis

The circadian clock is based on a transcriptional feedback loop with an essential time delay before feedback inhibition. Previous work has shown that PERIOD (PER) proteins generate circadian time cues through rhythmic nuclear accumulation of the inhibitor complex and subsequent interaction with the...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Beesley, Stephen, Kim, Dae Wook, D’Alessandro, Matthew, Jin, Yuanhu, Lee, Kwangjun, Joo, Hyunjeong, Young, Yang, Tomko, Robert J., Faulkner, John, Gamsby, Joshua, Kim, Jae Kyoung, Lee, Choogon
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7668169/
https://ncbi.nlm.nih.gov/pubmed/33106420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2003524117
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