Wake-sleep cycles are severely disrupted by diseases affecting cytoplasmic homeostasis

The circadian clock is based on a transcriptional feedback loop with an essential time delay before feedback inhibition. Previous work has shown that PERIOD (PER) proteins generate circadian time cues through rhythmic nuclear accumulation of the inhibitor complex and subsequent interaction with the...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Beesley, Stephen, Kim, Dae Wook, D’Alessandro, Matthew, Jin, Yuanhu, Lee, Kwangjun, Joo, Hyunjeong, Young, Yang, Tomko, Robert J., Faulkner, John, Gamsby, Joshua, Kim, Jae Kyoung, Lee, Choogon
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7668169/
https://ncbi.nlm.nih.gov/pubmed/33106420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2003524117
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