An allosteric peptide inhibitor of HIF-1α regulates hypoxia-induced retinal neovascularization

Retinal neovascularization (NV), a leading cause of vision loss, results from localized hypoxia that stabilizes the hypoxia-inducible transcription factors HIF-1α and HIF-2α, enabling the expression of angiogenic factors and genes required to maintain homeostasis under conditions of oxygen stress. H...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Usui-Ouchi, Ayumi, Aguilar, Edith, Murinello, Salome, Prins, Mitchell, Gantner, Marin L., Wright, Peter E., Berlow, Rebecca B., Friedlander, Martin
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7668029/
https://ncbi.nlm.nih.gov/pubmed/33106407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2017234117
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