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An allosteric peptide inhibitor of HIF-1α regulates hypoxia-induced retinal neovascularization
Retinal neovascularization (NV), a leading cause of vision loss, results from localized hypoxia that stabilizes the hypoxia-inducible transcription factors HIF-1α and HIF-2α, enabling the expression of angiogenic factors and genes required to maintain homeostasis under conditions of oxygen stress. H...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7668029/ https://ncbi.nlm.nih.gov/pubmed/33106407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2017234117 |
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