Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration

Photoreceptors are the most numerous and metabolically demanding cells in the retina. Their primary nutrient source is the choriocapillaris, and both the choriocapillaris and photoreceptors require trophic and functional support from retinal pigment epithelium (RPE) cells. Defects in RPE, photorecep...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Kurihara, Toshihide, Westenskow, Peter D, Gantner, Marin L, Usui, Yoshihiko, Schultz, Andrew, Bravo, Stephen, Aguilar, Edith, Wittgrove, Carli, Friedlander, Mollie SH, Paris, Liliana P, Chew, Emily, Siuzdak, Gary, Friedlander, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848091/
https://ncbi.nlm.nih.gov/pubmed/26978795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14319
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