Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration

Photoreceptors are the most numerous and metabolically demanding cells in the retina. Their primary nutrient source is the choriocapillaris, and both the choriocapillaris and photoreceptors require trophic and functional support from retinal pigment epithelium (RPE) cells. Defects in RPE, photorecep...

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Опубликовано в: :eLife
Главные авторы: Kurihara, Toshihide, Westenskow, Peter D, Gantner, Marin L, Usui, Yoshihiko, Schultz, Andrew, Bravo, Stephen, Aguilar, Edith, Wittgrove, Carli, Friedlander, Mollie SH, Paris, Liliana P, Chew, Emily, Siuzdak, Gary, Friedlander, Martin
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2016
Предметы:
Cell Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848091/
https://ncbi.nlm.nih.gov/pubmed/26978795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14319
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