miR-30a-5p inhibition promotes interaction of Fas(+) endothelial cells and FasL(+) microglia to decrease pathological neovascularization and promote physiological angiogenesis.

Ischemia-induced angiogenesis contributes to various neuronal and retinal diseases, and often results in neurodegeneration and visual impairment. Current treatments involve the use of anti-VEGF agents but are not successful in all cases. In this study we determined that miR-30a-5p is another importa...

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Detalhes bibliográficos
Publicado no:Glia
Main Authors: Murinello, Salome, Usui, Yoshihiko, Sakimoto, Susumu, Kitano, Maki, Aguilar, Edith, Friedlander, H. Maura, Schricker, Amelia, Wittgrove, Carli, Wakabayashi, Yoshihiro, Dorrell, Michael I., Westenskow, Peter D., Friedlander, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6349526/
https://ncbi.nlm.nih.gov/pubmed/30484883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23543
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