Discovery of a Selective, Covalent IRAK1 Inhibitor with Antiproliferative Activity in MYD88 Mutated B-Cell Lymphoma

[Image: see text] Interleukin 1 (IL-1) receptor-associated kinases (IRAKs) are serine/threonine kinases that play critical roles in initiating the innate immune response against foreign pathogens. Additionally, dysregulation of IRAK1 signaling plays a role in neoplastic disorders. For example, IRAK1...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Hatcher, John M., Yang, Guang, Wang, Li, Ficarro, Scott B., Buhrlage, Sara, Wu, Hao, Marto, Jarrod A., Treon, Steven P., Gray, Nathanael S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7667833/
https://ncbi.nlm.nih.gov/pubmed/33214835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00378
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